cdk 4 Search Results


cdk4  (ATCC)
94
ATCC cdk4
Cdk4, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
cdk4 - by Bioz Stars, 2026-02
94/100 stars
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gene exp cdk4 hs00175935 m1  (Thermo Fisher)
91
Thermo Fisher gene exp cdk4 hs00175935 m1
Gene Exp Cdk4 Hs00175935 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 91 stars, based on 1 article reviews
gene exp cdk4 hs00175935 m1 - by Bioz Stars, 2026-02
91/100 stars
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gene exp cdk4 mm00726334 s1  (Thermo Fisher)
88
Thermo Fisher gene exp cdk4 mm00726334 s1
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
Gene Exp Cdk4 Mm00726334 S1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gene exp cdk4 mm00726334 s1/product/Thermo Fisher
Average 88 stars, based on 1 article reviews
gene exp cdk4 mm00726334 s1 - by Bioz Stars, 2026-02
88/100 stars
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gene exp cdk4 hs00364847 m1  (Thermo Fisher)
94
Thermo Fisher gene exp cdk4 hs00364847 m1
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
Gene Exp Cdk4 Hs00364847 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gene exp cdk4 hs00364847 m1/product/Thermo Fisher
Average 94 stars, based on 1 article reviews
gene exp cdk4 hs00364847 m1 - by Bioz Stars, 2026-02
94/100 stars
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biotinylated mab  (Cell Signaling Technology Inc)
92
Cell Signaling Technology Inc biotinylated mab
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
Biotinylated Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/biotinylated mab/product/Cell Signaling Technology Inc
Average 92 stars, based on 1 article reviews
biotinylated mab - by Bioz Stars, 2026-02
92/100 stars
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11026 1 ap  (Proteintech)
96
Proteintech 11026 1 ap
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
11026 1 Ap, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/11026 1 ap/product/Proteintech
Average 96 stars, based on 1 article reviews
11026 1 ap - by Bioz Stars, 2026-02
96/100 stars
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p16 ink4a antibody  (Proteintech)
96
Proteintech p16 ink4a antibody
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
P16 Ink4a Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/p16 ink4a antibody/product/Proteintech
Average 96 stars, based on 1 article reviews
p16 ink4a antibody - by Bioz Stars, 2026-02
96/100 stars
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cdk4  (Santa Cruz Biotechnology)
96
Santa Cruz Biotechnology cdk4
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
Cdk4, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cdk4/product/Santa Cruz Biotechnology
Average 96 stars, based on 1 article reviews
cdk4 - by Bioz Stars, 2026-02
96/100 stars
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cdk4 6 inhibitors  (MedChemExpress)
94
MedChemExpress cdk4 6 inhibitors
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
Cdk4 6 Inhibitors, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cdk4 6 inhibitors/product/MedChemExpress
Average 94 stars, based on 1 article reviews
cdk4 6 inhibitors - by Bioz Stars, 2026-02
94/100 stars
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cdk4 6 inhibitor iv  (Santa Cruz Biotechnology)
86
Santa Cruz Biotechnology cdk4 6 inhibitor iv
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
Cdk4 6 Inhibitor Iv, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cdk4 6 inhibitor iv/product/Santa Cruz Biotechnology
Average 86 stars, based on 1 article reviews
cdk4 6 inhibitor iv - by Bioz Stars, 2026-02
86/100 stars
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cdk4  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc cdk4
CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , <t>Cdk4</t> , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.
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CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.

Journal: Stem Cell Reports

Article Title: CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation

doi: 10.1016/j.stemcr.2019.04.023

Figure Lengend Snippet: CCL5 Promotes Cell Cycling and Cell Survival after Irradiation (A) Left, representative flow cytometric analysis of KSL cells in G0 (Ki67 − 7-AAD − ), G 1 (Ki67 + 7-AAD − ), and G 2 /S/M (Ki67 + 7-AAD + ) phase at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. (B) Cell-cycle analysis of KSL cells at 72 h following 300 cGy in culture with CCL5 + TSF (CCL5) compared with TSF alone. n = 7–8 per group, ∗ p = 0.009 and p = 0.005 for G0/G1 and G2/S/M, respectively. (C) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 mRNA expression from KSL cells at 72 h following 300 cGy and treatment with TSF or 30 ng/mL CCL5. n = 3 per group, ∗ p = 0.0002, p = 0.004, and p = 0.004 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and TSF for each Cdk . (D) Schematic diagram of study design for E–6G. At 24 h after 500 cGy TBI, mice were injected with saline or 0.1 μg/g body weight of CCL5 and analyzed at 2 h postinjection. (E) RT-PCR analysis of Cdk2 , Cdk4 , and Cdk6 of BM Lin − cells. n = 4 per group, ∗ p = 0.003, p < 0.0001, and p < 0.0001 for Cdk2 , Cdk4 , and Cdk6 , respectively. Data are normalized to GAPDH and saline for each Cdk . (F) Representative flow cytometric Ki67/7-AAD cell-cycle analysis from KSL cells following 500 cGy TBI and treatment with CCL5 or saline. Nonirradiated control is shown for comparison. (G) Levels of G0/G1 and G2/S/M of KSL cells from irradiated CCL5- or saline-treated C57BL/6 mice. n = 5 per group, ∗ p < 0.001 for G0/G1 and G2/S/M. (H) Left, representative flow cytometric analysis of annexin V + KSL cells and progeny at 72 h following 300 cGy in culture with CCL5 (blue line) compared with TSF alone (gray line). Right, quantification of total annexin V + cells day 7 following 300 cGy and treatment with CCL5 or TSF alone. n = 3 per group, ∗ p < 0.0001. (I) Representative flow cytometric analysis and quantification of γ-H2AX in KSL and progeny following 300 cGy irradiation and 24 h culture with CCL5 (blue) or TSF alone (gray). Isotype is shown as black curve. n = 6 per group, ∗ p = 0.02. (J) Flow cytometric analysis of annexin V + from KSL cells and progeny of Ccr5 +/+ and Ccr5 −/− mice at 72 h following 300 cGy. n = 6 per group, ∗ p = 0.02. Data are shown as means ± SEM. Student's t test (two-tailed with unequal variance) was applied to the data.

Article Snippet: RT-PCR for Cdk2 , Cdk4 , and Cdk6 was performed on irradiated KSL cells or BM Lin − cells as specified in the figure legends (Thermo Fisher Scientific; Mm00443947_m1, Mm00726334_s1, Mm01311342_m1, respectively).

Techniques: Irradiation, Cell Cycle Assay, Reverse Transcription Polymerase Chain Reaction, Expressing, Injection, Saline, Control, Comparison, Two Tailed Test